Understanding Medication-Assisted Treatment (MAT)
MAT involves using medications to help treat substance use disorders by reducing cravings and alleviating withdrawal symptoms. It’s a concept many of us are already familiar with. For instance, prescribing a nicotine patch to a patient is a form of MAT.
For opioid use disorder, there are currently three FDA-approved medications: methadone, naltrexone, and buprenorphine. In outpatient settings, MAT is a well-established approach used by community-based substance abuse programs. Buprenorphine is increasingly being initiated in emergency departments and inpatient settings due to its favorable safety and efficacy profile and its ease of use.
Some people, both within and outside the medical community, have asked why we don’t simply wean patients off opioids entirely through detoxification. Well, data consistently shows that relapse rates with detox alone are extremely high, with studies indicating that most patients relapse within 30 days of discharge. In contrast, medications like buprenorphine help reduce the cravings that often lead to relapse, demonstrating stronger results across various outcomes, including treatment retention, return to daily responsibilities, and ultimately, reduced mortality.v
In response to the escalating opioid epidemic and the compelling data supporting the use of MAT for opioid use disorder, more providers are beginning to initiate treatment in the emergency department. In a 2015 randomized control trial published in JAMA, researchers at Yale University randomized emergency department patients presenting with opioid withdrawal to one of three treatment arms: (1) referral to outpatient treatment, (2) referral and brief counseling intervention, and (3) referral, counseling, and initiation of buprenorphine in the emergency department. The results were impressive: Receiving buprenorphine in the emergency department increased a patient’s likelihood of 30-day retention in treatment to 78%, a near-doubling relative to the group receiving brief counseling and referral alone.
Since then, numerous organizations have developed free open-access clinical pathways and educational materials to guide the use of buprenorphine in emergency department and inpatient settings. The California Bridge Program, for example, has created a straightforward buprenorphine guide and other educational materials that can be easily implemented.